BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling.

ABSTRACT:

Background

Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone is one of the most commonly damaged tissues. Damage to bone marrow mesenchymal stem cells (BM-MSCs) induced by radiation is thought to be a major cause of radiation-induced bone loss. Exosomes exhibit great therapeutic potential in the treatment of osteoporosis, but whether exosomes are involved in radiation-induced bone loss has not been thoroughly elucidated to date. The main purpose of this study is to investigate the role of exosomes derived from BM-MSCs in restoring recipient BM-MSC function and alleviating radiation-induced bone loss.

Methods

BM-MSC-derived exosomes were intravenously injected to rats immediately after irradiation. After 28 days, the left tibiae w

SUBMITTER: Zuo R 

PROVIDER: S-EPMC6334443 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature