The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region.

ABSTRACT:

Background

The cell-cycle inhibitor p57^kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57^kip2 expression is finely regulated by several epigenetic mechanisms, including paternal imprinting. Kcnq1ot1, a long non-coding RNA (LncRNA), whose gene maps to the p57^Kip2 imprinting domain, is expressed exclusively from the paternal allele and participates in the cis-silencing of the neighboring imprinted genes through chromatin-level regulation. In light of our previous evidence of a functional interaction between myogenic factors and imprinting control elements in the regulation of the maternal p57^Kip2 allele during muscle differentiation, we examined the possibility

SUBMITTER: Andresini O 

PROVIDER: S-EPMC6334472 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature