Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.

ABSTRACT:

Background

Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical neuroinflammatory event damages retinal ganglion cell axons in the optic nerve head during ocular hypertensive injury. We previously demonstrated that monocyte-like cells enter the optic nerve head in an ocular hypertensive mouse model of glaucoma (DBA/2 J), but their roles, if any, in mediating axon damage remain unclear.

Methods

To understand the function of these infiltrating monocyte-like cells, we used RNA-sequencing to profile their transcriptomes. Based on their pro-inflammatory molecular signatures, we hypothesized and confirmed that monocyte-platelet interactions occur in glaucomatous tissue. Furthermore, to te

SUBMITTER: Williams PA 

PROVIDER: S-EPMC6341618 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature