Dataset Information

Small dense LDL cholesterol is associated with metabolic syndrome traits independently of obesity and inflammation.

ABSTRACT:

Background

Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) has not been fully established.

Methods

A total of 1065 Chinese males (45.07 ± 11.08 years old) without diabetes and general obesity was recruited into a population-based, cross-sectional study. The MetS was defined based on the updated National Cholesterol Education Program/ Adult Treatment Panel III criteria for Asian Americans. Serum sdLDL-c concentration was measured by a homogeneous assay method and its relationship with MetS and its traits was investigated.

Results

Serum sdLDL-c concentrations increased gradually with increasing numbers of MetS components (p < 0.001) and the proportion of patients with MetS increased gradually with increasing sdLDL-c levels (p for trend< 0.001). For the second, third, and fourth sdLDL-c quartiles versus the first, the OR (95% CI) for MetS were 4.47(2.41,8.28), 5.47(2.97,10.07) and 8.39(4.58,15.38) (p < 0.001 for trend) after multivariate adjustment. The stratified analysis conducted according to LDL-c levels showed that the OR between serum sdLDL-c levels and MetS was greater in those LDL-c levels lower than 3.3 mmol/L (OR = 22.97; 95% CI, 7.64-69.09) than in those LDL-c levels higher than 3.3 mmol/L (OR = 17.49; 95% CI, 4.43-68.98). Mediation analysis showed sdLDL-c mediated 38.6% of the association of waist circumference with triglycerides, while the association between sdLDL-c and MetS components did not mediate by hsCRP.

Conclusions

This study found that high sdLDL-c concentrations were associated with the presence of MetS independently of central obesity and inflammation.

SUBMITTER: Fan J

PROVIDER: S-EPMC6341753 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Small dense LDL cholesterol is associated with metabolic syndrome traits independently of obesity and inflammation.

Fan Jiahua J Liu Yangqing Y Yin Songping S Chen Nixuan N Bai Xinxiu X Ke Qiuyi Q Shen Jia J Xia Min M

Nutrition & metabolism 20190121

<h4>Background</h4>Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) has not been fully established.<h4>Methods</h4>A total of 1065 Chinese males (45.07 ± 11.08 years old) without diabetes and general obesity was recruited into a population-based, cross-sectional study. The MetS was defined based on the updated National Cholesterol Educatio ...[more]

PMID: 30679939

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Dataset Information

Small dense LDL cholesterol is associated with metabolic syndrome traits independently of obesity and inflammation.

Background

Methods

Results

Conclusions

Publications

Small dense LDL cholesterol is associated with metabolic syndrome traits independently of obesity and inflammation.

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