Short, Tin-Free Synthesis of All Three Inthomycins.

ABSTRACT: The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross-couplings and an enantioselective Kiyooka aldol reaction.

SUBMITTER: Kumar M 

PROVIDER: S-EPMC6348375 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature