The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis.

ABSTRACT:

Objective

To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation.

Methods

We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate.

Results

Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH m

SUBMITTER: Conforti A 

PROVIDER: S-EPMC6366097 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature