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Ni-catalysed reductive arylalkylation of unactivated alkenes.

ABSTRACT: In this protocol Ni-catalysed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides has been accomplished, providing a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes. Notably, this new method circumvents the pregeneration of organometallics and demonstrates high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggest a reaction pathway with an intermediate reduction.

SUBMITTER: Jin Y

PROVIDER: S-EPMC6369408 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Ni-catalysed reductive arylalkylation of unactivated alkenes.

Jin Youxiang Y Wang Chuan C

Chemical science 20181204 6

In this protocol Ni-catalysed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides has been accomplished, providing a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes. Notably, this new method circumvents the pregeneration of organometallics and demonstrates high tolerance to a wide range of functional groups. The preliminary mechanistic investigations ...[more]

PMID: 30842845

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