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Metal-free C-H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source.

ABSTRACT: A facile and effective C-H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C-H mercaptalization of heteroarenes and a simple reaction system.

SUBMITTER: Xiao Y

PROVIDER: S-EPMC6369980 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Metal-free C-H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source.

Xiao Yan Y Jing Bing B Liu Xiaoxia X Xue Hongyu H Liu Yajun Y

Beilstein journal of organic chemistry 20190129

A facile and effective C-H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C-H mercaptalization of heteroarenes and a simple reaction system. ...[more]

PMID: 30800177

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