Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment.

ABSTRACT:

Background

Many premature infants with respiratory failure are deficient in surfactant, but the relationship to occurrence of bronchopulmonary dysplasia (BPD) is uncertain.

Methods

Tracheal aspirates were collected from 209 treated and control infants enrolled at 7-14 days in the Trial of Late Surfactant. The content of phospholipid, surfactant protein B, and total protein were determined in large aggregate (active) surfactant.

Results

At 24 h, surfactant treatment transiently increased surfactant protein B content (70%, p < 0.01), but did not affect recovered airway surfactant or total protein/phospholipid. The level of recovered surfactant during dosing was directly associated with content of surfactant protein B (r = 0.50, p < 0.00001) and inversely related to tota

SUBMITTER: Ballard PL 

PROVIDER: S-EPMC6377352 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature