Ontology highlight
ABSTRACT:
SUBMITTER: Reichhart N
PROVIDER: S-EPMC6381168 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20190219 1
Changes in cell function occur by specific patterns of intracellular Ca<sup>2+</sup>, activating Ca<sup>2+</sup>-sensitive proteins. The anoctamin (TMEM16) protein family has Ca<sup>2+</sup>-dependent ion channel activity, which provides transmembrane ion transport, and/or Ca<sup>2+</sup>-dependent phosphatidyl-scramblase activity. Using amino acid sequence analysis combined with measurements of ion channel function, we clarified the so far unknown Ano4 function as Ca<sup>2+</sup>-dependent, non ...[more]