Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study.

ABSTRACT:

Background

The importance of gut bacteria in human physiology, immune regulation, and disease pathogenesis is well established. In contrast, the composition and dynamics of the gut virome are largely unknown; particularly lacking are studies in pregnancy. We used comprehensive virome capture sequencing to characterize the gut virome of pregnant women with and without type 1 diabetes (T1D), longitudinally followed in the Environmental Determinants of Islet Autoimmunity study.

Methods

In total, 61 pregnant women (35 with T1D and 26 without) from Australia were examined. Nucleic acid was extracted from serial fecal specimens obtained at prenatal visits, and viral genomes were sequenced by virome capture enrichment. The frequency, richness, and abundance of viruses were compared

SUBMITTER: Wook Kim K 

PROVIDER: S-EPMC6386807 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature