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Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China.

ABSTRACT: This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The bla OXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.

SUBMITTER: Shu L 

PROVIDER: S-EPMC6395905 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Emergence of OXA-232 Carbapenemase-Producing <i>Klebsiella pneumoniae</i> That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China.

Shu Lingbin L   Dong Ning N   Lu Jun J   Zheng Zhiwei Z   Hu Jie J   Zeng Wenqing W   Sun Qiaoling Q   Chan Edward Wai-Chi EW   Zhou Hongwei H   Hu Fupin F   Chen Sheng S   Zhang Rong R  

Antimicrobial agents and chemotherapy 20190226 3

This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant <i>Klebsiella pneumoniae</i> among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The <i>bla</i><sub>OXA-232</sub> gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotyp  ...[more]

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