High-resolution population structure and runs of homozygosity reveal the genetic architecture of complex traits in the Lipizzan horse.

ABSTRACT:

Background

The sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of complex traits. In this study we derived the high-resolution population structure and levels of autozygosity of 377 Lipizzan horses originating from five different European stud farms utilizing the SNP genotype information of the high density 700 k Affymetrix Axiom™ Equine genotyping array. Scanning the genome for overlapping runs of homozygosity (ROH) shared by more than 50% of horses, we identified homozygous regions (ROH islands) in order to investigate the gene content of those candidate regions by gene ontology and enrichment analyses.

Results

The high-resolution population network approach revealed well-defined substructures according

SUBMITTER: Grilz-Seger G 

PROVIDER: S-EPMC6402180 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature