Dataset Information

Electroactive Artificial Muscles Based on Functionally Antagonistic Core-Shell Polymer Electrolyte Derived from PS-b-PSS Block Copolymer.

ABSTRACT: Electroactive ionic soft actuators, a type of artificial muscles containing a polymer electrolyte membrane sandwiched between two electrodes, have been intensively investigated owing to their potential applications to bioinspired soft robotics, wearable electronics, and active biomedical devices. However, the design and synthesis of an efficient polymer electrolyte suitable for ion migration have been major challenges in developing high-performance ionic soft actuators. Herein, a highly bendable ionic soft actuator based on an unprecedented block copolymer is reported, i.e., polystyrene-b-poly(1-ethyl-3-methylimidazolium-4-styrenesulfonate) (PS-b-PSS-EMIm), with a functionally antagonistic core-shell architecture that is specifically designed as an ionic exchangeable polymer electrolyte. The corresponding actuator shows exceptionally good actuation performance, with a high displacement of 8.22 mm at an ultralow voltage of 0.5 V, a fast rise time of 5 s, and excellent durability over 14 000 cycles. It is envisaged that the development of this high-performance ionic soft actuator could contribute to the progress toward the realization of the aforementioned applications. Furthermore, the procedure described herein can also be applied for developing novel polymer electrolytes related to solid-state lithium batteries and fuel cells.

SUBMITTER: Nguyen VH

PROVIDER: S-EPMC6402454 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Electroactive Artificial Muscles Based on Functionally Antagonistic Core-Shell Polymer Electrolyte Derived from PS-<i>b</i>-PSS Block Copolymer.

Nguyen Van Hiep VH Kim Jaehwan J Tabassian Rassoul R Kotal Moumita M Jun Kiwoo K Oh Jung-Hwan JH Son Ji-Myeong JM Manzoor Muhammad Taha MT Kim Kwang Jin KJ Oh Il-Kwon IK

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20181213 5

Electroactive ionic soft actuators, a type of artificial muscles containing a polymer electrolyte membrane sandwiched between two electrodes, have been intensively investigated owing to their potential applications to bioinspired soft robotics, wearable electronics, and active biomedical devices. However, the design and synthesis of an efficient polymer electrolyte suitable for ion migration have been major challenges in developing high-performance ionic soft actuators. Herein, a highly bendable ...[more]

PMID: 30886790

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Project description:Cationic non-viral vectors show great potential to introduce genetic material into cells, due to their ability to transport large amounts of genetic material and their high synthetic versatility. However, designing materials that are effective without showing toxic effects or undergoing non-specific interactions when applied systemically remains a challenge. The introduction of shielding polymers such as polyethylene glycol (PEG) can enhance biocompatibility and circulation time, however, often impairs transfection efficiency. Herein, a multicomponent polymer system is introduced, based on cationic and hydrophobic particles (P(nBMA46-co-MMA47-co-DMAEMA90), (PBMD)) with high delivery performance and a pH-responsive block copolymer (poly((N-acryloylmorpholine)-b-(2-(carboxy)ethyl acrylamide)) (P(NAM72-b-CEAm74), PNC)) as shielding system, with PNAM as alternative to PEG. The pH-sensitive polymer design promotes biocompatibility and excellent stability at extracellular conditions (pH 7.4) and also allows endosomal escape and thus high transfection efficiency under acidic conditions. PNC shielded particles are below 200 nm in diameter and showed stable pDNA complexation. Further, interaction with human erythrocytes at extracellular conditions (pH 7.4) was prevented, while acidic conditions (pH 6) enabled membrane leakage. The particles demonstrate transfection in adherent (HEK293T) as well as difficult-to-transfect suspension cells (K-562), with comparable or superior efficiency compared to commercial linear poly(ethylenimine) (LPEI). Besides, the toxicity of PNC-shielded particles was significantly minimized, in particular in K-562 cells and erythrocytes. In addition, a pilot in vivo experiment on bone marrow blood cells of mice that were injected with PNC-shielded particles, revealed slightly enhanced cell transfection in comparison to naked pDNA. This study demonstrates the applicability of cationic hydrophobic polymers for transfection of adherent and suspension cells in culture as well as in vivo by co-formulation with pH-responsive shielding polymers, without substantially compromising transfection performance. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1186/s12951-022-01528-0.

Dataset Information

Electroactive Artificial Muscles Based on Functionally Antagonistic Core-Shell Polymer Electrolyte Derived from PS-b-PSS Block Copolymer.

Publications

Electroactive Artificial Muscles Based on Functionally Antagonistic Core-Shell Polymer Electrolyte Derived from PS-<i>b</i>-PSS Block Copolymer.

Similar Datasets

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