Dynamic L-type Ca_V1.2 channel trafficking facilitates Ca_V1.2 clustering and cooperative gating.

ABSTRACT: L-type Ca_V1.2 channels are key regulators of gene expression, cell excitability and muscle contraction. Ca_V1.2 channels organize in clusters throughout the plasma membrane. This channel organization has been suggested to contribute to the concerted activation of adjacent Ca_V1.2 channels (e.g. cooperative gating). Here, we tested the hypothesis that dynamic intracellular and perimembrane trafficking of Ca_V1.2 channels is critical for formation and dissolution of functional channel clusters mediating cooperative gating. We found that Ca_V1.2 moves in vesicular structures of circular and tubular shape with diverse intracellular and submembrane trafficking patterns. Both microtubules and actin filaments are required for dynamic movement of

SUBMITTER: Ghosh D 

PROVIDER: S-EPMC6407617 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature