Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA.

ABSTRACT:

Background

Adrenocortical carcinoma (ACC) is a rare and aggressive malignant cancer in the adrenal cortex with poor prognosis. Though previous research has attempted to elucidate the progression of ACC, its molecular mechanism remains poorly understood.

Methods

Gene transcripts per million (TPM) data were downloaded from the UCSC Xena database, which included ACC (The Cancer Genome Atlas, n = 77) and normal samples (Genotype Tissue Expression, n = 128). We used weighted gene co-expression network analysis to identify gene connections. Overall survival (OS) was determined using the univariate Cox model. A protein-protein interaction (PPI) network was constructed by the search tool for the retrieval of interacting genes.

Results

To determine the critical g

SUBMITTER: Xia WX 

PROVIDER: S-EPMC6421058 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature