Single scan quantitative gradient recalled echo MRI for evaluation of tissue damage in lesions and normal appearing gray and white matter in multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic disease affecting the human central nervous system (CNS) and leading to neurologic disability. Although conventional MRI techniques can readily detect focal white matter (WM) lesions, it remains challenging to quantify tissue damage in normal-appearing gray matter (GM) and WM.

Purpose

To demonstrate that a new MRI biomarker, R2t*, can provide quantitative analysis of tissue damage across the brain in MS patients in a single scan.

Study type

Prospective.

Subjects

Forty-four MS patients and 19 healthy controls (HC).

Field strength/sequence

3T, quantitative gradient-recalled-echo (qGRE), Magnetization-prepared rapid gradient-echo, fluid-attenuated inversion recovery.

Assessment

Severity of tissue damage

SUBMITTER: Xiang B 

PROVIDER: S-EPMC6423972 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature