Dataset Information

Elucidating bidirectional relationship between metabolic syndrome and elevated faecal haemoglobin concentration: a Taiwanese community-based cohort study.

ABSTRACT:

Objectives

To elucidate the bidirectional temporal relationship between elevated faecal haemoglobin (f-Hb) concentration and metabolic syndrome (MetS).

Design

A longitudinal cohort study was conducted by utilising data on community-based periodical screening for colorectal cancer with faecal immunochemical test (FIT) and health check-up for MetS.

Setting

Population-based organised integrated service screening in Keelung city, Taiwan.

Participants

We enrolled a total of 62,293 community residents aged 40-79 years.

Main outcomes and measures

Bidirectional outcomes of FIT-positive and MetS were measured.

Results

The presence of MetS at baseline led to a statistically significant 31% elevated risk of being incident FIT-positive (adjusted HR, (aHR)=1.31, 95% CI: 1.14 to 1.51) whereas the effect of those with FIT-positive at baseline on incident MetS was not statistically significant (aHR=1.06, 95% CI: 0.89 to 1.25) after adjusting for relevant confounders. Such an effect was particularly noted for three individual components (abnormal waist circumference, higher fasting plasma glucose and lower high-density lipoprotein).

Conclusions

Our finding on the presence of MetS before FIT-positive based on bidirectional relationship assessment suggests the control of MetS may contribute to reducing the risk of colorectal neoplasia through the early surveillance of f-Hb. However, such a temporal epidemiological finding still needs to be verified by using other external data.

SUBMITTER: Ku MS

PROVIDER: S-EPMC6429718 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Elucidating bidirectional relationship between metabolic syndrome and elevated faecal haemoglobin concentration: a Taiwanese community-based cohort study.

Ku Mei-Sheng MS Fann Jean Ching-Yuan JC Chiu Sherry Yueh-Hsia SY Chen Hsiu-Hsi HH Hsu Chen-Yang CY

BMJ open 20190301 3

<h4>Objectives</h4>To elucidate the bidirectional temporal relationship between elevated faecal haemoglobin (f-Hb) concentration and metabolic syndrome (MetS).<h4>Design</h4>A longitudinal cohort study was conducted by utilising data on community-based periodical screening for colorectal cancer with faecal immunochemical test (FIT) and health check-up for MetS.<h4>Setting</h4>Population-based organised integrated service screening in Keelung city, Taiwan.<h4>Participants</h4>We enrolled a total ...[more]

PMID: 30826754

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Dataset Information

Elucidating bidirectional relationship between metabolic syndrome and elevated faecal haemoglobin concentration: a Taiwanese community-based cohort study.

Objectives

Design

Setting

Participants

Main outcomes and measures

Results

Conclusions

Publications

Elucidating bidirectional relationship between metabolic syndrome and elevated faecal haemoglobin concentration: a Taiwanese community-based cohort study.

Similar Datasets

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