Lifetime risk of prostate cancer overdiagnosis in Australia: quantifying the risk of overdiagnosis associated with prostate cancer screening in Australia using a novel lifetime risk approach.

ABSTRACT:

Objectives

To quantify the risk of overdiagnosis associated with prostate cancer screening in Australia using a novel lifetime risk approach.

Design

Modelling and validation of the lifetime risk method using publicly available population data.

Setting

Opportunistic screening for prostate cancer in the Australian population.

Participants

Australian male population (1982-2012).

Interventions

Prostate-specific antigen testing for prostate cancer screening.

Primary and secondary outcome measures

Primary: lifetime risk of overdiagnosis in 2012 (excess lifetime cancer risk adjusted for changing competing mortality); Secondary: lifetime risk of prostate cancer diagnosis (unadjusted and adjusted for competing mortality); Excess lifetime risk of prostate c

SUBMITTER: Pathirana T 

PROVIDER: S-EPMC6429722 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature