The effectiveness of ICSI versus conventional IVF in couples with non-male factor infertility: study protocol for a randomised controlled trial.

ABSTRACT:

Study questions

Does ICSI result in a higher live birth rate as compared with conventional IVF in couples with non-male factor infertility?

What is known already

ICSI is primarily indicated for severe male factor infertility. While the use of ICSI for couples with non-male factor infertility has been increasing worldwide, this is not supported by data from randomised controlled trials. Evidence from non-randomised studies suggest no benefit from ICSI compared with conventional IVF in non-male factor infertility, if not a harm.

Study design size duration

This randomised, open-label, multi-centre trial aims to compare the effectiveness of one ICSI cycle and one conventional IVF cycle in infertile couples with non-male factor infertility. A total of 1064 couples will be

SUBMITTER: Dang VQ 

PROVIDER: S-EPMC6436611 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature