Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke.

ABSTRACT:

Importance

The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke.

Objective

To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke.

Design, setting, and participants

Patient data from 7 randomized multicenter trials were pooled. These trials were conducted between December 2010 and April 2015 and included 1764 patients randomly assigned to receive either EVT or standard care (control). Follow-up infarct volume was assessed on computed tomography or ma

SUBMITTER: Boers AMM 

PROVIDER: S-EPMC6439953 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature