Epidemiological Typing of Serratia marcescens Isolates by Whole-Genome Multilocus Sequence Typing.

ABSTRACT: Serratia marcescens is an opportunistic bacterial pathogen. It is notorious for its increasing antimicrobial resistance and its potential to cause outbreaks of colonization and infections, predominantly in neonatal intensive care units (NICUs). There, its spread requires rapid infection control response. To understand its spread, detailed molecular typing is key. We present a whole-genome multilocus sequence typing (wgMLST) method for S. marcescens Using a set of 299 publicly available whole-genome sequences (WGS), we developed an initial wgMLST system consisting of 9,377 gene loci. This included 1,455 loci occurring in all reference genomes and 7,922 accessory loci. This closed system was validated using three geographically diverse collections of S. marcescens consis

SUBMITTER: Rossen JWA 

PROVIDER: S-EPMC6440794 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature