IGF-axis confers transformation and regeneration of fallopian tube fimbria epithelium upon ovulation.

ABSTRACT:

Background

The fallopian tube fimbria is regarded as the main tissue of origin and incessant ovulation as the main risk factor of ovarian high-grade serous carcinoma. Previously, we discovered the tumorigenesis activity of human ovulatory follicular fluid (FF) upon injection to the mammary fat pad of Trp53-null mice. We also found a mutagenesis activity of FF-ROS and a apoptosis-rescuing activity of Hb from retrograde menstruation. However, neither of them can explain the tumorigenesis activities of FF.

Methods

From two cohorts of ovulatory FF retrieved from IVF patients, the main growth factor responsible for the transformation of human fimbrial epithelial cells was identified. Mechanism of activation, ways of signal transduction of the growth factor, as well as the cellula

SUBMITTER: Hsu CF 

PROVIDER: S-EPMC6441876 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature