Ontology highlight
ABSTRACT:
SUBMITTER: Burmistrov V
PROVIDER: S-EPMC6442743 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20180523 13
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing one or two thiourea groups has been developed. Inhibition potency of the described compounds ranges from 50 μM to 7.2 nM. 1,7-(Heptamethylene)bis[(adamant-1-yl)thiourea] (6f) was found to be the most potent sEH inhibitor, among the thioureas tested. The inhibitory activity of the thioureas against the human sEH is closer to the value of activity against rat sEH rather than murine sEH. While being less active, thioureas are ...[more]