Gray Matter Microstructural Abnormalities and Working Memory Deficits in Individuals with Schizophrenia.

ABSTRACT: OBJECTIVE:Working memory impairments serve as prognostic factors for patients with schizophrenia. Working memory deficits are mainly associated with gray matter (GM) thickness and volume. We investigated the association between GM diffusivity and working memory in controls and individuals with schizophrenia. METHODS:T1 and diffusion tensor images of the brain, working memory task (letter number sequencing) scores, and the demographic data of 90 individuals with schizophrenia and 97 controls were collected from the SchizConnect database. T1 images were parcellated into the 68 GM Regions of Interest (ROI). Axial Diffusivity (AD), Fractional Anisotropy (FA), Radial Diffusivity (RD), and Trace (TR) were calculated for each of the ROIs. RESULTS:Compared to the controls, schizophrenia group show

SUBMITTER: Kim H 

PROVIDER: S-EPMC6444097 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature