New insights into the metal-induced oxidative degradation pathways of transthyretin.
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ABSTRACT:
SUBMITTER: Poltash ML
PROVIDER: S-EPMC6452628 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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New insights into the metal-induced oxidative degradation pathways of transthyretin.
Poltash Michael L ML Shirzadeh Mehdi M McCabe Jacob W JW Moghadamchargari Zahra Z Laganowsky Arthur A Russell David H DH
Chemical communications (Cambridge, England) 20190401 28
The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation. ...[more]
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