Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study.

ABSTRACT: The development of reduced-intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RDs) of peripheral blood stem cells (PBSCs). The effects of age on donation efficacy, toxicity, and long-term recovery in RDs are poorly understood. To address this we analyzed hematologic variables, pain, donation-related symptoms, and recovery in 1211 PBSC RDs aged 18 to 79 enrolled in the Related Donor Safety Study. RDs aged > 60 had a lower median CD34⁺ level before apheresis compared with younger RDs (age > 60, 59 × 10⁶/L; age 41 to 60, 81 × 10⁶/L; age 18 to 40, 121 × 10⁶/L; P < .001). This resulted in older donors undergoing more apheresis procedures (49% versus 30% ≥ 2 collections, P < .

SUBMITTER: Pulsipher MA 

PROVIDER: S-EPMC6453753 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature