Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage.

ABSTRACT:

Background aims

Light chain (AL) amyloidosis is a protein misfolding disease characterized by extracellular deposition of immunoglobulin light chains (LC) as amyloid fibrils. Patients with LC amyloid involvement of the heart have the worst morbidity and mortality. Current treatments target the plasma cells to reduce further production of amyloid proteins. There is dire need to understand the mechanisms of cardiac tissue damage from amyloid to develop novel therapies. We recently reported that LC soluble and fibrillar species cause apoptosis and inhibit cell growth in human cardiomyocytes. Mesenchymal stromal cells (MSCs) can promote wound healing and tissue remodeling. The objective of this study was to evaluate MSCs to protect cardiomyocytes affected by AL amyloid fibrils.

Meth

SUBMITTER: Lin Y 

PROVIDER: S-EPMC6456258 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature