Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study.

ABSTRACT:

Context

Osteoporosis is a metabolic bone disease. The effect of blood metabolites on the development of osteoporosis remains elusive.

Objective

To explore the relationship between blood metabolites and osteoporosis.

Design and methods

We used 2286 unrelated white subjects for the discovery samples and 3143 unrelated white subjects from the Framingham Heart Study (FHS) for the replication samples. The bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. Genome-wide single nucleotide polymorphism (SNP) genotyping was performed using Affymetrix Human SNP Array 6.0 (for discovery samples) and Affymetrix SNP 500K and 50K array (for FHS replication samples). The SNP sets significantly associated with blood metabolites were obtained from a reported

SUBMITTER: Liu L 

PROVIDER: S-EPMC6456956 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature