Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis.

ABSTRACT:

Context

Chronic pancreatitis (CP) is characterized by inflammation, fibrosis, and a loss of pancreatic acinar cells, which can result in exocrine and eventually endocrine deficiency. Pancreatitis has been reported to induce formation of new endocrine cells (neogenesis) in mice. Our recent data have implicated chromogranin A-positive hormone-negative (CPHN) cells as potential evidence of neogenesis in humans.

Objective

We sought to establish if CPHN cells were more abundant in CP in humans.

Design, setting, and participants

We investigated the frequency and distribution of CPHN cells and the expression of the chemokine C-X-C motif ligand 10 (CXCL10) and its receptor chemokine C-X-C motif receptor 3 in pancreas of nondiabetic subjects with CP.

Results

CPHN cell f

SUBMITTER: Moin ASM 

PROVIDER: S-EPMC6456995 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature