Dataset Information

Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis.

ABSTRACT:

Context

Chronic pancreatitis (CP) is characterized by inflammation, fibrosis, and a loss of pancreatic acinar cells, which can result in exocrine and eventually endocrine deficiency. Pancreatitis has been reported to induce formation of new endocrine cells (neogenesis) in mice. Our recent data have implicated chromogranin A-positive hormone-negative (CPHN) cells as potential evidence of neogenesis in humans.

Objective

We sought to establish if CPHN cells were more abundant in CP in humans.

Design, setting, and participants

We investigated the frequency and distribution of CPHN cells and the expression of the chemokine C-X-C motif ligand 10 (CXCL10) and its receptor chemokine C-X-C motif receptor 3 in pancreas of nondiabetic subjects with CP.

Results

CPHN cell frequency in islets was increased sevenfold in CP [2.1% ± 0.67% vs 0.35% ± 0.09% CPHN cells in islets, CP vs nonpancreatitis (NP), P < 0.01], as were the CPHN cells found as scattered cells in the exocrine areas (17.4 ± 2.9 vs 4.2 ± 0.6, CP vs NP, P < 0.001). Polyhormonal endocrine cells were also increased in CP (2.7 ± 1.2 vs 0.1 ± 0.04, CP vs NP, % of polyhormonal cells of total endocrine cells, P < 0.01), as was expression of CXCL10 in α and β cells.

Conclusion

There is increased islet endogenous expression of the inflammation marker CXCL10 in islets in the setting of nondiabetic CP and an increase in polyhormonal (insulin-glucagon expressing) cells. The increase in CPHN cells in CP, often in a lobular distribution, may indicate foci of attempted endocrine cell regeneration.

SUBMITTER: Moin ASM

PROVIDER: S-EPMC6456995 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis.

Moin Abu Saleh Md ASM Cory Megan M Choi Jennifer J Ong Allison A Dhawan Sangeeta S Dry Sarah M SM Butler Peter C PC Rizza Robert A RA Butler Alexandra E AE

The Journal of clinical endocrinology and metabolism 20180601 6

<h4>Context</h4>Chronic pancreatitis (CP) is characterized by inflammation, fibrosis, and a loss of pancreatic acinar cells, which can result in exocrine and eventually endocrine deficiency. Pancreatitis has been reported to induce formation of new endocrine cells (neogenesis) in mice. Our recent data have implicated chromogranin A-positive hormone-negative (CPHN) cells as potential evidence of neogenesis in humans.<h4>Objective</h4>We sought to establish if CPHN cells were more abundant in CP i ...[more]

PMID: 29659906

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Dataset Information

Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis.

Context

Objective

Design, setting, and participants

Results

Conclusion

Publications

Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis.

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