Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia.

ABSTRACT:

Context

Hypoglycemia, one of the major factors limiting optimal glycemic control in insulin-treated patients with diabetes, elicits a brain response to restore normoglycemia by activating counterregulation. Animal data indicate that local release of norepinephrine (NE) in the hypothalamus is important for triggering hypoglycemia-induced counterregulatory (CR) hormonal responses.

Objective

To examine the potential role of brain noradrenergic (NA) activation in humans during hypoglycemia.

Design

A hyperinsulinemic-hypoglycemic clamp was performed in conjunction with positron emission tomographic imaging.

Participants

Nine lean healthy volunteers were studied during the hyperinsulinemic-hypoglycemic clamp.

Design

Participants received intravenous injections

SUBMITTER: Belfort-DeAguiar R 

PROVIDER: S-EPMC6456998 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature