Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation.

ABSTRACT: Metabotropic glutamate receptor 2 (mGlu2) belongs to the group-II metabotropic glutamate (mGlu) receptors and is a neurotransmitter G protein-coupled receptor. The group-II mGlu receptors are promising antipsychotic targets, but the specific role of mGlu2 signaling remains unclear. Receptor tyrosine kinases (RTKs) are also believed to participate in brain pathogenesis. To investigate whether there is any communication between mGlu2 and RTKs, we generated a CHO-mGlu2 cell line that stably expresses mGlu2 and showed that activation of mGlu2 by LY379268, a group II mGlu agonist, was able to transactivate insulin-like growth factor 1 receptor (IGF-1R). We further determined that the G_i/o protein, G_βγ subunits, phospholipase C, and focal adhesion kinase (FAK) were involved

SUBMITTER: Hu YJ 

PROVIDER: S-EPMC6461959 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature