An efficient synthesis of the guaiane sesquiterpene (-)-isoguaiene by domino metathesis.

ABSTRACT: (-)-Isoguaiene was prepared from (S)-citronellal in only 9-10 steps with good overall yields. Either a trienyne or a dienediyne metathesis and highly diastereoselective organocatalytic Michael additions of aldehydes derived from (S)-citronellal served as the key transformations.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6466796 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature