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Phenalenones from a Marine-Derived Fungus Penicillium Sp.

ABSTRACT: Six new phenalenone derivatives (1?6), along with five known compounds (7?11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.

SUBMITTER: Park SC 

PROVIDER: S-EPMC6470642 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Phenalenones from a Marine-Derived Fungus <i>Penicillium</i> Sp.

Park Sung Chul SC   Julianti Elin E   Ahn Sungjin S   Kim Donghwa D   Lee Sang Kook SK   Noh Minsoo M   Oh Dong-Chan DC   Oh Ki-Bong KB   Shin And Jongheon AJ  

Marine drugs 20190318 3

Six new phenalenone derivatives (<b>1</b>⁻<b>6</b>), along with five known compounds (<b>7</b>⁻<b>11</b>) of the herqueinone class, were isolated from a marine-derived fungus <i>Penicillium</i> sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (<b>6</b>) and an acetone adduct of a triketone (<b>7</b>) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while <i>ent</i>  ...[more]

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