Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study.

ABSTRACT:

Background

Telomeres and telomerase play key roles in the chromosomal maintenance and stability. Recent epidemiological studies have shown that longer telomeres are associated with increased risk of several cancer types. However, epidemiological data for telomere length and risk of breast cancer are sparse.

Methods

We prospectively studied the association between telomere length and risk of breast cancer in 14,305 middle-aged or older Chinese women of the Singapore Chinese Health Study including 442 incident breast cancer cases after 12.3 years of follow-up. Relative telomere length in peripheral blood leukocytes was quantified using a validated monochrome multiple quantitative polymerase chain reaction method. The Cox proportional hazard regression method was used to estima

SUBMITTER: Samavat H 

PROVIDER: S-EPMC6471852 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature