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N-Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis.

ABSTRACT: The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group tolerance. In addition, we could demonstrate that other sulfoximidoyl derivatives like sulfonimidamides and sulfinamides proceed smoothly under the developed reaction conditions.

SUBMITTER: Wimmer A

PROVIDER: S-EPMC6480096 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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N-Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis.

Wimmer Alexander A König Burkhard B

Organic letters 20190402 8

The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group tolerance. In addition, we could demonstrate that other sulfoximidoyl derivatives like sulfonimidamides an ...[more]

PMID: 30938532

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