Dietary unsaturated fat increases HDL metabolic pathways involving apoE favorable to reverse cholesterol transport.

ABSTRACT:

Background

HDL that contains apolipoprotein E (apoE) is a subspecies especially active in steps in reverse cholesterol transport, a process that brings cholesterol from peripheral cells to the liver. Here, we studied the effect of dietary unsaturated fat compared with carbohydrate on the metabolism of HDL containing apoE.

Methods

We enrolled 9 adults who were overweight or obese and had below-average HDL-cholesterol in a crossover study of a high-fat diet, primarily unsaturated, and a low-fat, high-carbohydrate diet. A metabolic tracer study was performed after each diet period.

Results

Dietary fat increased the secretion, metabolism, and clearance of HDL subspecies containing apoE. Dietary fat increased the rate of clearance of large cholesterol-rich HDL containing a

SUBMITTER: Morton AM 

PROVIDER: S-EPMC6483656 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature