Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis.

ABSTRACT:

Background

Biomarkers of inflammation predictive of cystic fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments. A representative patient cohort would improve searching for believable, generalizable, reproducible and accurate biomarkers.

Methods

We recruited patients from Mountain West CF Consortium (MWCFC) care centers for prospective observational study of sputum biomarkers of inflammation. After informed consent, centers enrolled randomly selected patients with CF who were clinically stable sputum producers, 12 years of age and older, without previous organ transplantation.

Results

From December 8, 2014 through January 16, 2016, we enrolled 114 patients (53 male) with CF with con

SUBMITTER: Liou TG 

PROVIDER: S-EPMC6485181 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature