Ontology highlight
ABSTRACT:
SUBMITTER: Vieyra-Garcia P
PROVIDER: S-EPMC6485670 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Vieyra-Garcia Pablo P Crouch Jack D JD O'Malley John T JT Seger Edward W EW Yang Chao H CH Teague Jessica E JE Vromans Anna Maria AM Gehad Ahmed A Win Thet Su TS Yu Zizi Z Lowry Elizabeth L EL Na Jung-Im JI Rook Alain H AH Wolf Peter P Clark Rachael A RA
JCI insight 20190110 1
Psoralen plus UVA (PUVA) is an effective therapy for mycosis fungoides (MF), the skin-limited variant of cutaneous T cell lymphoma (CTCL). In low-burden patients, PUVA reduced or eradicated malignant T cells and induced clonal expansion of CD8+ T cells associated with malignant T cell depletion. High-burden patients appeared to clinically improve but large numbers of malignant T cells persisted in skin. Clinical improvement was linked to turnover of benign T cell clones but not to malignant T ce ...[more]