Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC6486330 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sun Yaping Y Oravecz-Wilson Katherine K Bridges Sydney S McEachin Richard R Wu Julia J Kim Stephanie H SH Taylor Austin A Zajac Cynthia C Fujiwara Hideaki H Peltier Daniel Christopher DC Saunders Thomas T Reddy Pavan P
The Journal of clinical investigation 20190408 5
DCs undergo metabolic reprogramming from a predominantly oxidative phosphorylation (OXPHOS) to glycolysis to mount an immunogenic response. The mechanism underpinning the metabolic reprogramming remains elusive. We demonstrate that miRNA-142 (miR-142) is pivotal for this shift in metabolism, which regulates the tolerogenic and immunogenic responses of DCs. In the absence of miR-142, DCs fail to switch from OXPHOS and show reduced production of proinflammatory cytokines and the ability to activat ...[more]