MiR-142-3p regulates synaptopathy-driven disease progression in multiple sclerosis.

ABSTRACT:

Aim

We recently proposed miR-142-3p as a molecular player in inflammatory synaptopathy, a new pathogenic hallmark of multiple sclerosis (MS) and of its mouse model experimental autoimmune encephalomyelitis (EAE), that leads to neuronal loss independently of demyelination. MiR-142-3p seems to be unique among potential biomarker candidates in MS, since it is an inflammatory miRNA playing a dual role in the immune and central nervous systems. Here, we aimed to verify the impact of miR-142-3p circulating in the cerebrospinal fluid (CSF) of MS patients on clinical parameters, neuronal excitability and its potential interaction with disease modifying therapies (DMTs).

Methods and results

In a cohort of 151 MS patients, we found positive correlations between CSF miR-142-3p levels a

SUBMITTER: De Vito F 

PROVIDER: S-EPMC9291627 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature