MiR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation.

ABSTRACT: MicroRNAs (miRNA) play an important role in post-transcriptional gene regulation of several physiological and pathological processes. In multiple sclerosis (MS), a chronic inflammatory and degenerative disease of the CNS, and in its mouse model, the experimental autoimmune encephalomyelitis (EAE), miRNA dysregulation has been mainly related to immune system dysfunction and white matter (WM) pathology. However, little is known about their role in gray matter pathology. Here, we explored miRNA involvement in the inflammation-driven alterations of synaptic structure and function, collectively known as synaptopathy, a neuropathological process contributing to excitotoxic neurodegeneration in MS/EAE. Particularly, we observed that miR-142-3p is increased in the CSF of patients with active MS an

SUBMITTER: Mandolesi G 

PROVIDER: S-EPMC6596761 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature