Prolonged electromechanical delay as an early predictor of trastuzumab-induced cardiotoxicity in patients undergoing treatment for breast cancer.

ABSTRACT:

Background

We aimed to investigate if left ventricular electromechanical delay (LVEMD) prolongation predicts trastuzumab-induced cardiotoxicity (TIC) in breast cancer patients.

Hypothesis

LVEMD prolongation on serial echocardiograms could be an indicator of subclinical TIC.

Methods

We included 237 breast cancer patients receiving trastuzumab chemotherapy, who underwent echocardiography at baseline and at 6 and 12 months after trastuzumab initiation. LVEMD was defined as the time from electrical activation to myocardial contraction. TIC was defined as left ventricular ejection fraction (LVEF) worsening to <55%, either as symptomatic decrease of ≥5% or asymptomatic decrease of ≥10%.

Results

During a mean follow-up of 547 days, TIC occurred in 27 patients (11.4%).

SUBMITTER: Choe JC 

PROVIDER: S-EPMC6489867 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature