Intravenous regadenoson with aminophylline reversal is safe and equivalent to intravenous adenosine infusion for fractional flow reserve measurements.

ABSTRACT:

Background

Small studies have shown that adenosine is equivalent to regadenoson when obtaining coronary fractional flow reserve (FFR) measurements. A study that also evaluates time and safety of aminophylline reversal of regadenoson effects has not been presented.

Hypothesis

Reversal of regadenoson with aminophylline is safe and equivalent to adenosine for FFR measurements.

Methods

Forty-six consecutive patients who underwent clinically indicated FFRs at the time of coronary angiography were enrolled between 4/2012 and 5/2014. Each patient had FFR measured using adenosine 140 mcg/kg/min IV, and following return to baseline, FFR was measured using regadenoson 400 mcg IV, which then was reversed with aminophylline 150 mg IV. Time to baseline hemodynamics was measured. A

SUBMITTER: Edward JA 

PROVIDER: S-EPMC6489999 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature