Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.

ABSTRACT:

Background

Allergic asthma is characterized by chronic inflammation and remodelling of the airways, associated with dysregulated type 2 immune responses and allergen-specific IgE. T follicular helper cells (T_FH ) are crucial in T-dependent B-cell responses and have been implicated in allergic airway disease (AAD). T_FH , unlike other CD4⁺ T cells, are uniquely reliant on continuous ICOS signalling to maintain their phenotype after T-cell priming; therefore, disrupting this signal can impair T_FH responses. However, the contribution of T_FH to disease during chronic aero-allergen exposure and the therapeutic potential of targeting these cells have not been evaluated.

Methods

To establish AAD, female BALB/c mice were repeated

SUBMITTER: Uwadiae FI 

PROVIDER: S-EPMC6492018 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature