Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice.

ABSTRACT:

Aims

The receptor tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile. In this study, we investigate the potential role of endothelial ErbB4 receptor signaling in the brain.

Results

Here, we show that the endothelial cell-specific deletion of ErbB4 induces decreased exploratory behavior in adult mice. However, the water maze task for spatial memory and the memory reconsolidation test reveal no changes; additionally, we observe no impairment in CaMKII phosphorylation in Cdh5Cre;ErbB4^f/f mice, which indicates that the endothelial ErbB4 deficit leads to decreased exploratory activity rather than direct memory deficits. Furthermore, decreased brain metabolism, which was measured using micro-positron emission tomography,

SUBMITTER: Wu G 

PROVIDER: S-EPMC6492688 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature