The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFκB-Dependent Manner.

ABSTRACT: The family of NADPH oxidases represents an important source of reactive oxygen species (ROS) within the cell. Nox4 is a special member of this family as it constitutively produces H₂O₂ and its loss promotes inflammation. A major cellular component of inflammation is the macrophage population, which can be divided into several subpopulations depending on their phenotype, with proinflammatory M(LPS+IFNγ) and wound-healing M(IL4+IL13) macrophages being extremes of the functional spectrum. Whether Nox4 is expressed in macrophages is discussed controversially. Here, we show that macrophages besides a high level of Nox2 indeed express Nox4. As Nox4 contributes to differentiation of many cells, we hypothesize that Nox4 plays a role in determining the polarization and

SUBMITTER: Helfinger V 

PROVIDER: S-EPMC6501210 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature