Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation.

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process where older patients accumulate distinct subclones defined by recurring somatic mutations in hematopoietic stem cells. CHIP's implications for stem cell transplantation have been harder to identify due to the high degree of mutational heterogeneity that is present within the genetically distinct subclones. In order to gain a better understanding of CHIP and the impact of clonal dynamics on transplantation outcomes, we created a mathematical model of clonal competition dynamics. Our analyses highlight the importance of understanding competition intensity between healthy and mutant clones. Importantly, we highlight the risk that CHIP poses in leading to dominance of precancerous mutant clones and the risk

SUBMITTER: Park DS 

PROVIDER: S-EPMC6505959 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature