Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4⁺ memory T cells.

ABSTRACT: All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, including KLRB1, KLRG1, GPR56, and KLRF1, help define low, high, or exhausted cytokine producers within human peripheral and intrahepatic CD4⁺ memory T-cell populations. Highest simultaneous production of TNF and IFN-γ is observed in KLRB1⁺KLRG1⁺GPR56⁺ CD4 T cells. By contrast, KLRF1 expression is associated with T-cell exhaustion and reduced TNF/IFN-γ production. Lastly, TCRβ repertoire analysis and in vitro differentiation support a regulated, progressi

SUBMITTER: Truong KL 

PROVIDER: S-EPMC6531457 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature