Torque Teno Virus for Risk Stratification of Acute Biopsy-Proven Alloreactivity in Kidney Transplant Recipients.

ABSTRACT:

Background

Drug-induced immunosuppression in kidney transplant recipients is crucial to prevent allograft rejection, but increases risk for infectious disease. Immunologic monitoring to tailor immunosuppressive drugs might prevent alloreactivity and adverse effects simultaneously. The apathogenic torque teno virus (TTV) reflects the immunocompetence of its host and might act as a potential candidate for a holistic monitoring.

Methods

We screened all 1010 consecutive patients from the prospective Vienna Kidney Transplant Cohort Study for availability of allograft biopsies and adequately stored sera for TTV quantification by polymerase chain reaction.

Results

Patients with acute biopsy-proven alloreactivity according to the Banff classification (n = 33) showed lower lev

SUBMITTER: Strassl R 

PROVIDER: S-EPMC6534191 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature